פרופסור ארד מיכאל

מנהל שרות קרדיומיופתיות במרכז הלב, ביה"ח שיבא
פרופ' חבר בבית הספר לרפואה, אוניברסיטת תל אביב
מומחה לקרדיולוגיה משנת 1998
מומחה לרפואה פנימית משנת 1995

בוגר תיכון "הנדסאים" ליד אוניברסיטת תל אביב – 1980
בוגר בוגר בית הספר לרפואה באוניברסיטה העברית ירושלים – 1988
בוגר מוסמך (מסטר) בפיזיולוגיה של הלב באוניברסיטה העברית – 1986

בוגר Fellowship בגנטיקה של מחלות שריר הלב והשתלמות באי ספיקת לב בבית הספר לרפואה Harvard
ובית החולים Brigham and Women's בבוסטון, ארה"ב

האגוד הקרדיולוגי בישראל
האגוד הקרדיולוגי האירופי European Society of Cardiology
האגודה לאי ספיקת לב באגוד הקרדיולוגי האירופי European Society of Cardiology
החוג למחלות שריר לב והפריקרד, אגוד הקרדיולוגי האירופי European Society of Cardiology
האגודה הישראלית לחקר הלב, International Society for Heart Research

פרסומים עיקריים:

Arad M, Benson DW, Perez-Atayde AR, McKenna WJ, Sparks EA, Kanter RJ, McGarry K, Seidman JG, Seidman CE.
Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy.
J Clin Invest. 2002 Feb;109(3):357-62.

Arad M, Maron BJ, Gorham JM, Johnson WH Jr, Saul JP, Perez-Atayde AR, Spirito P, Wright GB, Kanter RJ, Seidman CE, Seidman JG.
Glycogen storage diseases presenting as hypertrophic cardiomyopathy.
N Engl J Med. 2005 Jan 27;352(4):362-72.

Arad M, Penas-Lado M, Monserrat L, Maron BJ, Sherrid M, Ho CY, Barr S, Karim A, Olson TM, Kamisago M, Seidman JG, Seidman CE.
Gene mutations in apical hypertrophic cardiomyopathy.
Circulation. 2005 Nov 1;112(18):2805-1

Arad M, Adler Y, Koren-Morag N, Natanzon S, Sela BA, Ben Dov I, Shechter M, Schwammenthal E, Freimark D.
Exercise training in advanced heart failure patients: discordance between improved exercise tolerance and unchanged NT-proBNP levels.
Int J Cardiol. 2008 May 7;126(1):114-9.

Katz G, Arad M, Eldar M. Catecholaminergic polymorphic ventricular tachycardia – from bedside to bench and over.
Current Problems in Cardiology 2009;34(1):1-44

Katz G, Khoury A, Kurtzwald E, Hochhauser E, Porat E, Shainberg A, Seidman JG, Seidman CE, Lorber A, Eldar M, Arad M.
Optimizing catecholaminergic polymorphic ventricular tachycardia therapy in calsequestrin-mutant mice.
Heart Rhythm. 2010 Nov;7(11):1676-82.

Klempfner R, Kamerman T, Schwammenthal E, Nahshon A, Hay I, Goldenberg I, Freimark D, Arad M.
Efficacy of exercise training in moderately symptomatic hypertrophic cardiomyopathy patients – A pilot study .
Eur J Prev Cardiol. 2015 ;22(1):13-9. Epub 2013 Aug 82013.

Katz G, Shainberg A, Hochhauser E, Kurtzwald-Josefson E, Issac A, El-Ani D, Aravot D, Afek A, Seidman JG, Seidman CE, Eldar M, Arad M.
The role of mutant protein level in autosomal recessive catecholamine dependent polymorphic ventricular tachycardia (CPVT2).
Biochem Pharmacol. 2013 Dec 1;86(11):1576-83.

Peled,Y, Gramlich, M, Yoskovitz,G, Feinberg, MS, Afek A, Polak -Charcon, S, Pras, E, Sela BA, Konen E, Thierfelder L, Freimark, D, Gerull, B*, Arad, M*.
Titin Mutation in Familial Restrictive Cardiomyopathy.
International J Cardiology 2014; 171: 24–30

Arad, M, Nussbaum, T, Blechman, I, Feinberg, MS, Koren-Morag, N, Peled, Y, Freimark, D. Prevalence and Clinical Predictors of Reverse Remodeling in Patients with Dilated Cardiomyopathy. Isr Med Assoc J. 2014;16: 405-411.

Arad M, Monserrat L, Haron-Khun S, Seidman JG, Seidman CE, Arbustini E, Glikson M, Freimark D. Merits and pitfalls of genetic testing in HCM clinic. Isr Med Assoc J 2014;16:707-713.

Kuperstein R, Blechman I, Ben-Zikri S, Freimark D, Arad M. Reverse remodeling and the mechanism of mitral regurgitation Improvement in patients with dilated cardiomyopathy. Cardiology J. 2015;22(4):391-6.

Leviner DB, Hochhauser E, Arad M. Inherited cardiomyopathies–Novel therapies.
Pharmacol Ther. 2015 Nov;155:36-48

Goland S, Weinstein JM, Zalik A, Kuperstein R, Zilberman L, Shimoni S, Arad M,
Ben Gal T, George J. Angiogenic Imbalance and Residual Myocardial Injury in
Recovered Peripartum Cardiomyopathy Patients. Circ Heart Fail. 2016 Nov;9(11).

Kurtzwald-Josefson E, Yadin D, Harun-Khun S, Waldman M, Aravot D, Shainberg A, Eldar M, Hochhauser E, Arad M. Viral delivered gene therapy to treat catecholamine-dependent polymorphic ventricular tachycardia (CPVT2) in mouse models. Heart Rhythm. 2017 Jul;14(7):1053-1060.

Arad M. Cardiac Danon disease: Insights and challenges. Int J Cardiol. 2017 Oct 15;245:211-212.

Wanner C, Arad M, Baron R, Burlina A, Elliott PM, Feldt-Rasmussen U, Fomin VV, Germain DP, Hughes DA, Jovanovic A, Kantola I, Linhart A, Mignani R, Monserrat L, Namdar M, Nowak A, Oliveira JP, Ortiz A, Pieroni M, Spada M, Tylki-Szymańska A, Tøndel C, Viana-Baptista M, Weidemann F, Hilz MJ. European expert consensus statement on therapeutic goals in Fabry disease. Mol Genet Metab. 2018;Jul;124(3):189-203.

Kuperstein R, Klempfner R, Ofek E, Maor E, Freimark D, Sternik L, GoldenbergI, Raanani E, Arad M. De novo mitral regurgitation as a cause of heart failure exacerbation in patients with hypertrophic cardiomyopathy. Int J Cardiol. 2018 Feb 1;252:122-127

Eisen B, Ben Jehuda R, Cuttitta AJ, Mekies LN, Reiter I, Ramchandren S, Arad M, Michele DE, Binah O. Generation of Duchenne muscular dystrophy patient-specific induced pluripotent stem cell line lacking exons 45-50 of the dystrophin gene (IITi001-A). Stem Cell Res. 2018 Apr 3;29:111-114

Younis A, Freimark D, Klempfner R, Peled Y, Brodov Y, Goldenberg I, Arad M. Sub-acute vs. Late-onset Presentation of Onco-therapy related Cardio-toxicity: Predictors of Cardiac Function Recovery and Long Term Outcome. IMAJ 2018 Aug;20(8):486-490.

Wasserstrum Y, Barriales-Villa R, Fernández-Fernández X, Adler Y, Lotan D, Peled Y, Klempfner R, Kuperstein R, Shlomo N, Sabbag A, Freimark D, Monserrat L, Arad M. The Impact of Diabetes Mellitus on the Clinical Phenotype of Hypertrophic Cardiomyopathy. Eur Heart J 2019; 40(21):1671-1677,

Naftali-Shani N, Molotski N, Nevo-Caspi Y, Arad M, Kuperstein R, Amit U, Huberc I, Zeltzer LA, Levich A, Abbas H, Monserrat L, Paret G, Leor J. Modeling Peripartum Cardiomyopathy With Human Induced Pluripotent Stem Cells Reveals Distinctive Abnormal Function of Cardiomyocytes. Circulation. 2018 Dec 4;138(23):2721-2723.

Eisen B, Ben Jehuda R, Cuttitta AJ, Mekies LN, Shemer Y, Baskin P, Reiter I, Willi L, Freimark D, Gherghiceanu M, Monserrat L, Scherr M, Hilfiker-Kleiner D, Arad M, Michele DE, Binah O. Electrophysiological abnormalities in induced pluripotent stem cell-derived cardiomyocytes generated from Duchenne muscular dystrophy patients. J Cell Mol Med. 2019 Mar;23(3):2125-2135.

Wasserstrum Y, Barbarova I, Lotan D, Kuperstein R, Shechter M, Freimark D, Segal G, Klempfner R, Arad M. Efficacy and safety of exercise rehabilitation in patients with hypertrophic cardiomyopathy. J Cardiol. 2019 Nov;74(5):466-472.

Seferović PM, Polovina M, Arad M et al, Heart failure in cardiomyopathies: A position paper from the Heart Failure Association of the European Society of Cardiology. Eur J Heart Failure. Eur J Heart Fail. 2019 May;21(5):553-576

Arow M, Waldman M, Yadin D, Nudelman V, Shainberg A, Abraham NG, Freimark D,
Kornowski R, Aravot D, Hochhauser E, Arad M. Sodium-glucose cotransporter 2
inhibitor Dapagliflozin attenuates diabetic cardiomyopathy. Cardiovasc Diabetol.
2020 Jan 10;19(1):7. doi: 10.1186/s12933-019-0980-4.

Adler Y, Charron P, Imazio M et al, European Society of Cardiology (ESC). 2015 ESC Guidelines for the diagnosis and management of pericardial diseases: The Task Force for the Diagnosis and Management of Pericardial Diseases of the
European Society of Cardiology (ESC)Endorsed by: The European Association for Cardio Thoracic Surgery (EACTS). Eur Heart J. 2015 Nov 7;36(42):2921-64.

Caforio ALP, Adler Y, Agostini C, Allanore Y, Anastasakis A, Arad M, et al. Diagnosis
and management of myocardial involvement in systemic immune-mediated diseases: a
position statement of the European Society of Cardiology Working Group on
Myocardial and Pericardial Disease. Eur Heart J. 2017 Jun 26. doi:10.1093/eurheartj/ehx321.